La presente edición es la 28ª de Major League Soccer (MLS), la principal liga de fútbol profesional de los Estados Unidos y Canadá. Los Angeles Football Club es el campeón defensor.
En esta edición participarán 29 clubes debido a la incorporación de St. Louis City SC como un equipo de expansión en la Conferencia Oeste y con Nashville SC regresando a la Conferencia Este. La temporada regular se detuvo del 21 de julio al 19 de agosto para la Leagues Cup -aquí los equipos de la MLS jugaron contra clubes de la Liga MX-.
Argentinos
Partidos
Final
Sábado 09 de Diciembre, 18:00 
Columbus Crew 2 (33′ J.C. Hernández (pen.); 37′ Y. Yeboah) vs 
Los Angeles FC 1 (74′ D. Bouanga) 
Semifinales
Sábado 02 de Diciembre, 20:00 
Cincinnati 2 (14′ B. Vázquez; 45(+3)’ L. Acosta) vs Columbus Crew 3 (75′ A. Powell (e.c.); 86′ D. Rossi; 115′ C. Ramírez)
23:30 Los Angeles FC 2 (44′ R. Hollingshead; 80′ F. Escobar (e.c.)) vs 
Houston Dynamo 0
Cuartos de final Sábado 25, 22.00 Cincinnati 1 (90(+4)’ Y. Mosquera) vs 
Philadelphia 0 Domingo 26, 21.00 Houston Dynamo 1 (39′ F. Escobar) vs 
Kansas City 0 Sábado 25, 19.30 
Orlando City 0 vs Columbus Crew 2 (93′ C. Ramírez; 118′ J.C. Hernández) Domingo 26, 23.30 
Seattle Sounders 0 vs Los Ángeles FC 1 (30′ D. Bouanga)
Octavos de final Domingo 29 de Octubre, Cincinnati 3 (23′ A. Barreal; 35′ L. Acosta; 89′ A. Barreal) vs New York RB 0 Sábado 04 de Noviembre, 20:00 New York RB 1 (45′ T. Barlow) vs Cincinnati 1 (75′ A. Boupendza) Penales: 7-8 Sábado 28 de Octubre, Philadelphia 3 (19′ D. Gazdag (pen.); 26′ M. Uhre; 37′ N. Harriel) vs New England 1 (68′ G. Bou)
Miércoles 08 de Noviembre, 21:00 New England 0 vs Philadelphia 1 (79′ C. Donovan) Miércoles 01 de Noviembre, 20:30 2 (45(+1)’ y 51′ J.C. Hernández) vs Atlanta United 0 Martes 07 de Noviembre, 21:00 Atlanta United 4 (38′ G. Giakoumakis; 45(+4)’ X. Silva; 83′ E. Mosquera; 88′ T. Almada) vs Columbus Crew 2 (45′ J.C. Hernández; 90(+5)’ M. Arfsten) Lunes 30 de Octubre, 20:00 Orlando City 1 (41′ W. Cartagena) vs Nashville SC Martes 07 de Noviembre, 23:00 Nashville SC vs Orlando City Domingo 29, St. Louis City 1 vs Kansas City 4 (28′ T. Parker; 27′ L. Ndenbe; 36′ R. Walter; 39′ G. Kinda; 61′ D. Salloi) Domingo 05 de Noviembre, 19:00 Kansas City 2 (45(+1)’ L. Ndenbe; 73′ D. Salloi) vs St. Louis City 1 (86′ C. Pompeu) Domingo 29, Houston Dynamo 2 (22′ H. Herrera; 79′ A. Bassi) vs Real Salt Lake 1 (54′ D. Luna)
Lunes 06 de Noviembre, 23:00 Real Salt Lake 1 (70′ J. Savarino) vs Houston Dynamo 1 (28′ A. Bassi) Penales: 5-4 Sábado 28 de Octubre, Los Angeles FC 5 (18′ R. Hollingshead; 29′ D. Bouanga; 52′ R. Hollingshead; 64′ D. Bouanga; 80′ J.D. Murillo) vs Vancouver 2 (27′ B. White; 40′ S. Adekugbe) Domingo 05 de Noviembre, 21:30 Vancouver 0 vs Los Angeles FC 1 (24′ D. Bouanga (pen.)) Lunes 30 de Octubre, 22:00 Seattle Sounders 2 (43′ A. Rusnak (pen.); 74′ J. Morris) vs Dallas 0 Sábado 04 de Noviembre, 22:00 Dallas 3 (6′ P. Arriola; 18′ J. Ferreira (pen.); 89′ J. Obrian) vs Seattle Sounders 1 (48′ J. Morris)
Repechaje New York RB 5 vs Charlotte 2 Kansas 0 vs San José 0 (4-2 en penales)
Posiciones
Zona A
| # | Equipo | Pts | PJ | PG | PE | PP | GF | GC | DIF |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Cincinnati | 69 | 34 | 20 | 9 | 5 | 57 | 39 | +18 |
| 2 |  Orlando City | 63 | 34 | 18 | 9 | 7 | 55 | 39 | +16 |
| 3 |  Columbus Crew | 57 | 34 | 16 | 9 | 9 | 67 | 46 | +21 |
| 4 |  Philadelphia | 55 | 34 | 15 | 10 | 9 | 57 | 41 | +16 |
| 5 |  New England | 55 | 34 | 15 | 10 | 9 | 58 | 46 | +12 |
| 6 |  Atlanta United | 51 | 34 | 13 | 12 | 9 | 66 | 53 | +13 |
| 7 |  Nashville SC | 49 | 34 | 13 | 10 | 11 | 39 | 32 | +7 |
| 8 |  New York RB | 43 | 34 | 11 | 10 | 13 | 36 | 39 | -3 |
| 9 |  Charlotte FC | 43 | 34 | 10 | 13 | 11 | 45 | 52 | -7 |
| 10 |  Montreal | 41 | 34 | 12 | 5 | 17 | 36 | 52 | -16 |
| 11 |  New York FC | 41 | 34 | 9 | 14 | 11 | 35 | 39 | -4 |
| 12 |  DC United | 40 | 34 | 10 | 10 | 14 | 45 | 49 | -4 |
| 13 |  Chicago Fire | 40 | 34 | 10 | 10 | 14 | 39 | 51 | -12 |
| 14 |  Inter Miami | 34 | 34 | 9 | 7 | 18 | 41 | 54 | -13 |
| 15 |  Toronto FC | 22 | 34 | 4 | 10 | 20 | 26 | 59 | -33 |
Zona B
| # | Equipo | Pts | PJ | PG | PE | PP | GF | GC | DIF |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  St. Louis City | 56 | 34 | 17 | 5 | 12 | 62 | 45 | +17 |
| 2 |  Seattle Sounders | 53 | 34 | 14 | 11 | 9 | 41 | 32 | +9 |
| 3 |  Los Angeles FC | 52 | 34 | 14 | 10 | 10 | 54 | 39 | +15 |
| 4 |  Houston Dynamo | 51 | 34 | 14 | 9 | 11 | 51 | 38 | +13 |
| 5 |  Real Salt Lake | 50 | 34 | 14 | 8 | 12 | 48 | 50 | -2 |
| 6 |  Vancouver | 48 | 34 | 12 | 12 | 10 | 55 | 48 | +7 |
| 7 |  Dallas | 46 | 34 | 11 | 13 | 10 | 41 | 37 | +4 |
| 8 |  Kansas City | 44 | 34 | 12 | 8 | 14 | 48 | 51 | -3 |
| 9 |  SJ Earthquakes | 44 | 34 | 10 | 14 | 10 | 39 | 43 | -4 |
| 10 |  Portland Timbers | 43 | 34 | 11 | 10 | 13 | 46 | 58 | -12 |
| 11 |  Minnesota | 41 | 34 | 10 | 11 | 13 | 46 | 51 | -5 |
| 12 |  Austin FC | 39 | 34 | 10 | 9 | 15 | 49 | 55 | -6 |
| 13 |  L.A. Galaxy | 36 | 34 | 8 | 12 | 14 | 51 | 67 | -16 |
| 14 |  Colorado | 27 | 34 | 5 | 12 | 17 | 26 | 54 | -28 |
*Los ganadores de cada zona avanzan a cuartos de final. Del 2º al 7º a octavos. 8º y 9º a Repechaje.
Jugados
| Fecha 38 | |||
| Sábado 21 de Octubre, 19:00 | Charlotte FC 13′ K. Vargas | 1-0 | Inter Miami |
| 19:00 | Columbus Crew 17′ J.C. Hernández; 50′ D. Nagbe | 2-1 | Montreal 7′ S. Ibrahim |
| 19:00 | Cincinnati 25′ D. Badji; 45(+2)’ L. Acosta | 2-2 | Atlanta United 12′ G. Giakoumakis; 32′ G. Giakoumakis |
| 19:00 | Nashville SC | 0-1 | New York RB 90(+4)’ J. Tolkin (pen.) |
| 19:00 | New England 25′ G. Bou (pen.); 41′ G. Bou | 2-1 | Philadelphia 16′ J. Carranza |
| 19:00 | New York FC 64′ J. Fernández | 1-0 | Chicago Fire |
| 19:00 | Toronto FC | 0-2 | Orlando City 63′ D. McGuire; 74′ D. McGuire |
| 22:00 | Colorado | 0-1 | Real Salt Lake 74′ D. Luna |
| 22:00 | L.A. Galaxy 24′ R. Edwards | 1-4 | Dallas 3′ B. Kamungo; 13′ E. Twumasi; 30′ B. Kamungo; 45(+2)’ J. Obrian |
| 22:00 | Portland Timbers 80′ F. Mora | 1-3 | Houston Dynamo 11′ G. Dorsey; 48′ A. Carrasquilla; 71′ G. Dorsey |
| 22:00 | SJ Earthquakes 17′ C. Espinoza | 1-1 | Austin FC 32′ O. Wolff |
| 22:00 | Kansas City 28′ J. Russell; 31′ R. Walter; 78′ J. Russell | 3-1 | Minnesota 82′ M. Boxall |
| 22:00 | St. Louis City | 0-2 | Seattle Sounders 23′ A. Rusnak; 38′ T. Parker (e.c.) |
| 22:00 | Vancouver 58′ A. Ahmed | 1-1 | Los Angeles FC 34′ D. Bouanga |
| Fecha 37 | |||
| Sábado 07 de Octubre, 20:30 | Atlanta United 90(+7)’ M. Robinson | 1-1 | Columbus Crew 65′ J.C. Hernaández |
| 20:30 | Montreal 28′ S. Ibrahim; 35′ K. Opoku; 64′ M. Choiniere; 76′ M. Toye | 4-1 | Portland Timbers 86′ F. Boli |
| 20:30 | DC United 45′ M. Klich; 62′ C. Durkin | 2-0 | New York FC |
| 20:30 | Inter Miami | 0-1 | Cincinnati 78′ A. Barreal |
| 20:30 | New York RB 45′ T. Barlow; 48′ Luquinhas; 65′ Luquinhas | 3-0 | Toronto FC |
| 20:30 | Orlando City 31′ D. McGuire; 37′ F. Torres; 45′ I. Angulo | 3-2 | New England 42′ C. Gil; 90(+3)’ C. Gil |
| 20:30 | Philadelphia | 0-0 | Nashville SC |
| 21:30 | Austin FC 75′ L. Vaisanen; 90(+4)’ G. Chiellini (e.c.) | 2-4 | Los Angeles FC 13′ T. Tillman; 45(+1)’ D. Bouanga (pen.); 54′ D. Bouanga; 68′ C. Olivera |
| 21:30 | Chicago Fire 23′ A. Westwood; 58′ K. Swiderski (pen.) | 0-2 | Charlotte FC |
| 21:30 | Dallas 57′ J. Obrian | 1-1 | SJ Earthquakes 3′ J. Ebobisse |
| 21:30 | Houston Dynamo 3′ N. Quiñones; 8′ A. Bassi; 28′ N. Quiñones; 41′ C. Baird; 84′ Artur | 5-1 | Colorado 53′ C. Bassett |
| 21:30 | Minnesota 33′ H. Dotson; 45′ T. Pukki; 60′ T. Pukki; 67′ T. Pukki; 76′ T. Pukki | 5-2 | L.A. Galaxy 41′ T. Boyd; 82′ D. Joveljic |
| 22:30 | Real Salt Lake 81′ B. Vera; 89′ J. Savarino | 2-3 | Kansas City 4′ E. Thommy; 29′ J. Russell 77′ A. Pulido; |
| 23:30 | Seattle Sounders | 0-0 | Vancouver |
| Fecha 36 | |||
| Miércoles 04 de Octubre, 20:30 | Montreal 90(+6)’ L. Lappalainen | 1-1 | Houston Dynamo 10′ Artur |
| 20:30 | Charlotte FC 8′ K. Swiderski (pen.); 45(+2)’ K. Swiderski (pen.); 56′ B. Dejaegere | 3-0 | Toronto FC |
| 20:30 | Cincinnati 68′ L. Acosta (pen.) | 1-2 | New York RB 12′ F. Amaya; 17′ E. Manoel |
| 20:30 | New England 48′ T. Chancalay | 1-2 | Columbus Crew 20′ D. Rossi; 86′ M.M. Amundsen |
| 20:30 | Philadelphia 39′ D. Gazdag; 41′ M. Uhre; 45(+3)’ J. Carranza | 3-2 | Atlanta United 56′ T. Almada (pen.); 77′ E. Mosquera |
| 21:30 | Austin FC 11′ W. Bruin; 21′ S. Driussi; 64′ M. Hedges | 3-0 | DC United |
| 21:30 | Chicago Fire 49′ X. Shaqiri; 62′ M. Haile-Selassie; 65′ M. Haile-Selassie; 73′ X. Shaqiri | 4-1 | Inter Miami 53′ J. Martínez (pen.) |
| POST | Dallas 37′ A. Velasco | 1-1 | Colorado 25′ R. Navarro |
| 21:30 | Nashville SC | 0-1 | Orlando City 44′ D. McGuire |
| 23:30 | Los Angeles FC 6′ D. Bouanga; 36′ D. Bouanga; 45(+1)’ D. Bouanga; 46′ M. Tapias (e.c.); 67′ F.Y. Krastev | 5-1 | Minnesota 4′ H. Dotson |
| 23:30 | Seattle Sounders 9′ J. Morris; 90(+6)’ C. Roldán | 2-1 | L.A. Galaxy 54′ D. Costa |
| 23:30 | Vancouver 58′ B. White; 82′ S. Berhalter; 90(+6)’ R. Laryea | 3-0 | St. Louis City |
| Fecha 35 | |||
| Sábado 30 de Septiembre, 20:30 | Columbus Crew 72′ J.C. Hernández (pen.) | 1-1 | Philadelphia 50′ N. Harriel |
| 20:30 | Inter Miami 90(+5)’ T. Avilés | 1-1 | New York FC 77′ S. Rodríguez; |
| 20:30 | New England 64′ N. Buck; 85′ D. Romney | 2-1 | Charlotte FC 84′ K. Swiderski |
| 20:30 | New York RB | 0-1 | Chicago Fire 64′ G. Koutsias |
| 20:30 | Orlando City 19′ J. Sirois (e.c.); 50′ D. Thorhallsson; 54′ F. Torres | 3-0 | Montreal |
| 20:30 | Toronto FC 39′ J. Osorio; 44′ J. Osorio | 2-3 | Cincinnati 28′ B. Vázquez; 35′ B. Vázquez; 72′ A. Boupendza |
| 21:30 | Houston Dynamo | 0-0 | Dallas |
| 21:30 | Minnesota 56′ T. Pukki | 1-1 | SJ Earthquakes 82′ P. Marie |
| 21:30 | Nashville SC | 0-0 | Seattle Sounders |
| 21:30 | St. Louis City 73′ S. Adeniran; 75′ J. Stroud; 80′ Klauss; 85′ Klauss | 4-1 | Kansas City 90(+3)’ W. Agada |
| 22:30 | Colorado 41′ A. Maxso | 1-0 | Austin FC |
| 23:30 | L.A. Galaxy 10′ E. Zavaleta; 43′ D. Costa; 45(+1)’ E. Zavaleta | 3-3 | Portland Timbers 5′ S. Moreno; 38′ E. Zavaleta (e.c.); 76′ F. Mora |
| 23:30 | Vancouver 2′ B. White; 57′ R. Gauld (pen.) | 2-2 | DC United 11′ C. Benteke; 62′ M. Klich |
| Domingo 01 de Octubre, 21:00 | Los Angeles FC | 0-1 | Real Salt Lake 72′ C. Arango |
| Fecha 34 | |||
| Sábado 23 de Septiembre, 20:30 | Atlanta United 30′ X. Silva; 33′ T. Almada; 46′ G. Giakoumakis; 89′ E. Mosquera | 4-1 | Montreal 40′ A. Hamdi |
| 20:30 | DC United 21′ C. Benteke; 36′ C. Benteke; 45(+2)’ C. Benteke (pen.) | 3-5 | New York RB 17′ O. Fernández; 44′ O. Fernández (pen.); 45(+5)’ C. Harper; 58′ S. Nealis; 90(+3)’ J. Tolkin |
| 20:30 | Cincinnati 45(+1)’ A. Barreal; 50′ A. Boupendza; 78′ L. Acosta | 3-0 | Charlotte FC |
| 20:30 | Philadelphia | 0-0 | Los Angeles FC |
| 21:30 | Chicago Fire 18′ B. Gutiérrez; 54′ G. Giménez | 2-2 | New England 17′ T. Chancalay; 59′ C. Gil |
| 21:30 | Dallas 43′ J. Obrian | 1-1 | Columbus Crew 24′ N. Burgess (e.c.) |
| 21:30 | Minnesota 48′ T. Pukki (pen.) | 1-2 | St. Louis City 64′ Klauss; 73′ N. Blom |
| 21:30 | Kansas City 7′ J. Russell (pen.); 45(+6)’ W. Agada | 2-1 | Houston Dynamo 45(+9)’ T. Hadebe |
| 22:30 | Real Salt Lake 47′ B. Vera; 65′ J. Glad | 2-1 | Vancouver 17′ B. White |
| 23:30 | Portland Timbers 19′ Antony; 30′ S. Moreno 71′ F. Mora | 3-2 | Colorado 31′ D. Rubio; 43′ A. Gutman |
| 23:30 | SJ Earthquakes 74′ M. Hoppe | 1-1 | Nashville SC 50′ T. Bunbury |
| Domingo 24, 14.00 | New York FC 2′ A. Perea; 45(+4)’ A. Jasson; 54′ J. Fernández | 3-0 | Toronto FC |
| 20:30 | Orlando City 66′ D. McGuire | 1-1 | Inter Miami 52′ D. Ruíz |
| 22:30 | Austin FC 11′ A. Ring; 45′ E. Finlay; 75′ E. Rigoni | 3-3 | L.A. Galaxy 45′ R. Puig; 89′ D. Joveljik; 90′ M. Barrios |
| Fecha 33 | |||
| Miércoles 20 de Septiembre, 20:30 | Montreal 53′ K. Opoku | 1-1 | Cincinnati 90(+7)’ L. Acosta (pen.) |
| 20:30 | Charlotte FC 55′ J. Meram; 61′ K. Swiderski | 2-2 | Philadelphia 70′ Q. Sullivan; 90(+7)’ D. Gazdag (pen) |
| 20:30 | Columbus Crew 8′ J.C. Hernández (pen.); 16′ J.C. Hernández (pen.); 23′ J.C. Hernández | 3-0 | Chicago Fire |
| 20:30 | DC United 80′ G. Pirani | 1-1 | Atlanta United 14′ S. Lobzhanidze |
| 20:30 | Inter Miami 45(+3)’ F. Farías; 54′ R. Taylor; 73′ B. Cremaschi; 87′ R. Taylor | 4-0 | Toronto FC |
| 20:30 | New York FC 37′ M. Bakrar; 68′ T. Magno | 2-0 | Orlando City |
| 20:30 | New York RB 7′ E. Rigoni (e.c.) | 1-1 | Austin FC 44′ S. Driussi |
| 21:30 | Houston Dynamo 13′ H. Herrera; 44′ G. Dorsey; 73′ I. Franco; 84′ I. Aliyu | 4-1 | Vancouver 90′ E. Sviatchenko (e.c.) |
| 21:30 | Kansas City | 0-3 | Nashville SC 29′ F. Picault; 66′ H. Mukhtar; 76′ J. Maher |
| 21:30 | St. Louis City | 0-0 | Los Angeles FC |
| 22:30 | Colorado 80′ C. Bassett | 1-2 | Seattle Sounders 34′ L. Chu; 56′ A. Rusnak |
| 22:30 | Real Salt Lake 43′ C. Arango | 1-3 | Dallas 56′ P. Arriola; 62′ J. Ferreira (pen.); 71′ J. Ferreira |
| 23:30 | L.A. Galaxy 16′ B. Sharp; 63′ B. Sharp; 71′ B. Sharp; 82′ D. Fagundez | 4-3 | Minnesota 19′ T. Pukki; 41′ B. Hlongwane; 45(+5)’ B. Hlongwane |
| 23:30 | Portland Timbers 45(+3)’ C. Paredes; 58′ Evander | 2-1 | SJ Earthquakes 60′ M. Hoppe |
| Fecha 32 | |||
| Sábado 16, 16:30 | New York FC | 0-0 | New York RB |
| 18:00 | Atlanta United 36′ T.M. Nkita; 41′ K. Miller (e.c.); 44′ B. Lennon; 76′ G. Giakoumakis; 89′ T. Wolff; | 5-2 | Inter Miami 25′ L. Campana; 53′ L. Campana (pen.) |
| 20:30 | Montreal | 0-0 | Chicago Fire |
| 20:30 | Charlotte FC | 0-0 | DC United |
| 20:30 | Orlando City 48′ M. Ojeda; 73′ F. Torres; 86′ R. Enrique; 90(+7)’ R. Enrique | 4- 3 | Columbus Crew 16′ J. Gressel; 56′ D. Rossi; 68′ J.C. Hernández |
| 20:30 | Philadelphia 23′ J. Martínez; 37′ D. Gazdag (pen.) | 2-2 | Cincinnati 49′ A. Boupendza; 76′ B. Vázquez |
| 20:30 | Toronto FC 50′ D. Kerr | 1-2 | Vancouver 56′ T. Blackmon; 66′ B. White |
| 21:30 | Dallas 14′ J. Obrian | 1-1 | Seattle Sounders 57′ A. Roldán |
| 21:30 | Houston Dynamo 42′ C. Baird | 1-1 | St. Louis City 87′ Klauss |
| 21:30 | Minnesota | 0-1 | Kansas City 84′ G. Kinda |
| 22:30 | Colorado 48′ C. Bassett; 62′ C. Harris | 2-1 | New England 90(+2)’ O. González |
| 23:30 | Los Angeles FC 23′ D. Bouanga; 33′ R. Hollingshead; 75′ D. Bouanga; 84′ T. Tillman | 4-2 | L.A. Galaxy 25′ B. Sharp; 59′ M. Yoshida |
| 23:30 | SJ Earthquakes 2′ J. Ebobisse; 15′ Tonhao | 2-1 | Real Salt Lake 44′ C. Arango |
| Domingo 17, 21:30 | Austin FC 75′ S. Driussi | 1-2 | Portland Timbers 39′ F. Mora; 64′ Evander |
| Fecha 31 | |||
| Sábado 09 de Septiembre, 20:30 | DC United | 0-0 | SJ Earthquakes |
| 20:30 | Inter Miami 25′ L. Campana (pen.); 45′ L. Campana; 60′ F. Farías | 3-2 | Kansas City 9′ D. Salloi; 78′ A. Pulido |
| 23:30 | Portland Timbers 28′ L. Mabiala; 53′ C. Bravo | 2-0 | Los Angeles FC |
| Fecha 30 | |||
| Sábado 02 de Septiembre 16:30 | New York FC 55′ M. Bakrar | 1-1 | Vancouver 60′ R. Gauld (pen.) |
| 20:30 | Montreal 52′ K. Opoku; 68′ J. Vilsaint | 2-4 | Columbus Crew 14′ G. Corbo (e.c.); 22′ J.C. Hernandez; 43′ J.C. Hernandez; 65′ J.C. Hernandez (pen.) |
| 20:30 | DC United 9′ C. Benteke; 20′ T. Ku-Dipietro; 40′ C. Teran (e.c.); 90(+1)’ C. Benteke | 4-0 | Chicago Fire |
| 20:30 | Cincinnati | 0-1 | Orlando City 44′ F. Torres |
| 20:30 | New England 28′ T. Chancalay; 47′ T. Chancalay | 2-2 | Austin FC 27′ E. Rigoni; 90(+4)’ A. Ring |
| 21:30 | Dallas 4′ P. Arriola; 62′ B. Kamungo | 2-2 | Atlanta United 44′ G. Giakoumakis; 58′ S. Lobzhanidze |
| 21:30 | Nashville SC 90(+8)’ H. Mukhtar (pen.) | 1-1 | Charlotte FC 90(+3)’ S. Arfield |
| 21:30 | Kansas City 31′ A. Pulido; 44′ A. Pulido | 2-1 | St. Louis City 22′ S. Adeniran |
| 22:30 | Real Salt Lake 19′ B. Vera; 49′ C. Arango | 2-0 | Colorado |
| 23:30 | L.A. Galaxy | 0-0 | Houston Dynamo |
| 23:30 | SJ Earthquakes 16′ C. Cowell | 1-1 | Minnesota 4′ T. Pukki |
| 23:30 | Seattle Sounders 9′ R. Ruidíaz; 30′ L. Chu | 2-2 | Portland Timbers 67′ D. Asprilla; 70′ Evander |
| Domingo 03, 20:30 | Philadelphia 29′ J. Glesnes; 57′ D. Lowe; 58′ J. Carranza; 76′ D. Gazdag | 4-1 | New York RB 11′ O. Fernández |
| 23:00 | Los Angeles FC 90′ R. Hollingshead | 1-3 | Inter Miami 14′ F. Farías; 51′ J. Alba; 83′ L. Campana |
| Fecha 29 | |||
| Miércoles 30, 20:30 | Atlanta United 10′ E. Mosquera | 1-2 | Cincinnati 75′ L. Acosta; 80′ B. Vazquez |
| 20:30 | Charlotte FC 81′ E. Copetti (pen.) | 1-1 | Orlando City 88′ M. Ojeda |
| 20:30 | Inter Miami | 0-0 | Nashville SC |
| 20:30 | New England 30′ G. Vrioni | 1-0 | New York RB |
| 20:30 | New York FC 29′ A. Jasson; 37′ M. Bakrar | 2-0 | Montreal |
| 20:30 | Toronto FC 23′ L. Insigne; 58′ D. Kerr; 63′ J. Osorio | 3-1 | Philadelphia 45′ J. Carranza |
| 21:30 | Austin FC 72′ S. Driussi | 1-2 | Seattle Sounders 48′ J. Morris; 90′ A. Rusnak |
| 21:30 | Chicago Fire | 0-1 | Vancouver 19′ B. White |
| 21:30 | Houston Dynamo 14′ C. Baird; 90′ I. Aliyu | 2-0 | Columbus Crew |
| 21:30 | Minnesota 18′ E. Reynoso (pen.); 28′ E. Reynoso; 43′ T. Pukki | 3-0 | Colorado |
| 21:30 | St. Louis City 82′ A. Markanich; 85′ N. Thorisson | 2-1 | Dallas |
| 23:30 | Portland Timbers 13′ S. Moreno; 64′ F. Mora | 2-1 | Real Salt Lake 82′ C. Arango |
| 23:30 | SJ Earthquakes 29′ Calegari (e.c.); 31′ J. Ebobisse | 2-3 | L.A. Galaxy 16′ T. Boyd; 50′ R. Puig; 61′ D. Joveljic (pen.) |
| Fecha 28 | |||
| Sábado 28, 20:30 | Atlanta United 26′ X. Silva; 46′ T. Almada; 57′ M. Robinson; 87′ S. Lobzhanidze | 4-0 | Nashville SC |
| 20:30 | Montreal 86′ G. Campbell | 1-0 | New England |
| 20:30 | Charlotte FC 29′ A. Westwood; 75′ S. Arfield | 2-1 | Los Angeles FC 67′ M. González |
| 20:30 | Columbus Crew 21′ D. Rossi; 88′ J. Russell-Rowe | 2-0 | Toronto FC |
| 20:30 | DC United 88′ T. Ku-Dipietro | 1-3 | Philadelphia 5′ M. Uhre; 13′ J. McGlynn; 38′ D. Gazdag (pen.) |
| 20:30 | Cincinnati 6′ A. Boupendza; 52′ J. Moreno; 59′ N. Hagglund | 3-0 | New York FC |
| 20:30 | New York RB | 0-2 | Inter Miami 37′ D. Gómez; 89′ L. Messi |
| 20:30 | Orlando City 48′ F. Torres; 90(+1)’ F. Torres (pen.) | 2-1 | St. Louis City 78′ R. Alm |
| 21:30 | Dallas 90(+7)’ N. Burgess | 1-0 | Austin FC |
| 21:30 | Kansas City 3′ D. Salloi; 42′ J. Russell; 69′ E. Thommy | 3-0 | SJ Earthquakes |
| 22:30 | Real Salt Lake | 0-3 | Houston Dynamo 9′ C. Baird; 29′ D. Steres; 75′ A. Carrasquilla |
| 23:30 | L.A. Galaxy 29′ T. Boyd; 72′ R. Puig; 90′ B. Sharp (pen.) | 3-0 | Chicago Fire |
| 23:30 | Portland Timbers 53′ F. Mora; 85′ Evander | 2-3 | Vancouver 13′ R. Gauld; 36′ B. White; 60′ R. Gauld (pen.) |
| Domingo 27, 17:30 | Minnesota 56′ Y. Gómez (e.c.) | 1-1 | Seattle Sounders 17′ Y. Gómez |
| Fecha 27 | |||
| Domingo 20 de Agosto, 20:30 | Columbus Crew 15′ A. Morris; 23′ J.C. Hernandez (pen.); 90(+6)’ J. Russell-Rowe | 3-0 | Cincinnati |
| 20:30 | New York FC | 0-2 | Minnesota 53′ J. Gregus; 90(+5)’ M. Garcia |
| 20:30 | New York RB 88′ J. Tolkin | 1-0 | DC United |
| 20:30 | Toronto FC 66′ F. Bernardeschi; 90(+4)’ F. Bernardeschi | 2-3 | Montreal 18′ M. Choiniere; 25′ A. Mabika (e.c.); 79′ M. Choiniere (pen.) |
| 21:30 | Chicago Fire 47′ M. Pineda | 1-3 | Orlando City 50′ W. Cartagena; 54′ I. Angulo; 68′ F. Torres (pen.) |
| 21:30 | Houston Dynamo 5′ A. Bassi (pen.); 11′ N. Quiñones; 14′ C. Baird; 45(+3)’ F. Escobar; 63′ B. Smith | 5-0 | Portland Timbers |
| 22:30 | St. Louis City 22′ T. Parker; 45(+2)’ N. Gioacchini; 50′ N. Gioacchini; 72′ S. Adeniran; 88′ T. Ostrak; 90(+5)’ S. Adeniran | 6-3 | Austin FC 61′ S. Driussi (pen.); 87′ W. Bruin; 90(+1)’ E. Rigoni |
| 23:30 | Seattle Sounders | 0-2 | Atlanta United 11′ G. Giakoumakis; 65′ G. Giakoumakis |
| 23:30 | Vancouver | 0-1 | SJ Earthquakes 43′ C. Espinoza |
| Miércoles 23, 23.30 | Los Angeles FC 19′ M. Bogusz; 29′ C. Vela; 36′ R. Hollingshead; 83′ C. Olivera | 4-0 | Colorado |
| Miércoles 27 de septiembre, 20.30 | Philadelphia 25′ Q. Sullivan | 1-1 | Dallas 36′ A. Velasco |
| Sábado 14 de octubre, 21.30 | Nashville SC 19′ D. McCarty; 30′ S. Surridge; 45(+3)’ S. Surridge | 3-2 | New England 49′ T. Chancalay; 71′ T. Chancalay |
| 23.30 | L.A. Galaxy 7′ D. Joveljic; 34′ D. Costa | 2-2 | Real Salt Lake 45(+1)’ A. Julio; 76′ D. Luna |
| Miércoles 18/10 | Inter Miami 45(+6)’ N. Stefanelli; 84′ R. Robinson | 2-2 | Charlotte FC 45′ E. Copetti; 52′ K. Vargas |
| Fecha 26 | |||
| Sábado 15 de Julio, 20:30 | Atlanta United | 1-2 | Orlando City |
| 20:30 | Montreal | 2-0 | Charlotte FC |
| 20:30 | Cincinnati | 3-1 | Nashville SC |
| 20:30 | New England | 4-0 | DC United |
| 20:30 | Philadelphia | 2-0 | New York FC |
| 21:30 | Austin FC | 2-1 | Kansas City |
| 21:30 | Chicago Fire | 1-0 | Toronto FC |
| 21:30 | Minnesota | 1-1 | Los Angeles FC |
| 21:30 | St. Louis City | 3-0 | Inter Miami |
| 22:30 | Colorado | 0-0 | Houston Dynamo |
| 22:30 | Real Salt Lake | 3-1 | New York RB |
| 23:30 | Portland Timbers | 3-2 | Columbus Crew |
| 23:30 | Seattle Sounders | 1-1 | Dallas |
| 23:30 | Vancouver | 4-2 | L.A. Galaxy |
| Fecha 25 | |||
| Miércoles 12 de Julio, 20:30 | New England | 2-1 | Atlanta United |
| 20:30 | New York RB | 1-2 | Cincinnati |
| 21:30 | Chicago Fire | 3-0 | Montreal |
| 21:30 | Houston Dynamo | 0-3 | Minnesota |
| 21:30 | Nashville SC | 0-2 | Philadelphia |
| 21:30 | Kansas City | 2-2 | Real Salt Lake |
| 23:30 | SJ Earthquakes | 2-0 | Seattle Sounders |
| 23:30 | Vancouver | 2-1 | Austin FC |
| Los Angeles FC | 3-0 | St. Louis City |
| Fecha 24 | |||
| Sábado 08 de Julio | |||
| 20:30 | Montreal | 0-1 | Atlanta United |
| 20:30 | Charlotte FC | 2-2 | Cincinnati |
| 20:30 | Columbus Crew | 1-1 | New York FC |
| 20:30 | DC United | 2-2 | Inter Miami |
| 20:30 | New York RB | 2-1 | New England |
| 20:30 | Toronto FC | 0-1 | St. Louis City |
| 21:30 | Chicago Fire | 1-0 | Nashville SC |
| 21:30 | Houston Dynamo | 2-2 | Kansas City |
| 21:30 | Minnesota | 1-4 | Austin FC |
| 22:30 | Colorado | 2-1 | Dallas |
| 22:30 | Real Salt Lake | 4-0 | Orlando City |
| 23:30 | L.A. Galaxy | 3-1 | Philadelphia |
| 23:30 | Los Angeles FC | 1-1 | SJ Earthquakes |
| 23:30 | Vancouver | 2-3 | Seattle Sounders |
| Fecha 23 | |||
| Martes 04 de Julio | |||
| 20:30 | Inter Miami | 2-2 | Columbus Crew |
| 20:30 | Orlando City | 4-0 | Toronto FC |
| 21:30 | Dallas | 0-1 | DC United |
| 22:30 | Colorado | 0-0 | Portland Timbers |
| 23:30 | L.A. Galaxy | 2-1 | Los Angeles FC |
| Miércoles 05 de Julio | |||
| 20:30 | New York FC | 1-1 | Charlotte FC |
| Domingo 10 de Septiembre | |||
| 21:00 | L.A. Galaxy | 2-2 | St. Louis City |
| Fecha 22 | |||
| Sábado 01 de Julio | |||
| 20:30 | Montreal | 0-1 | New York FC |
| 20:30 | Columbus Crew | 2-1 | New York RB |
| 20:30 | Cincinnati | 2-2 | New England |
| 20:30 | Inter Miami | 1-1 | Austin FC |
| 20:30 | Orlando City | 3-1 | Chicago Fire |
| 20:30 | Toronto FC | 0-1 | Real Salt Lake |
| 21:30 | Dallas | 2-0 | Los Angeles FC |
| 21:30 | Minnesota | 4-1 | Portland Timbers |
| 21:30 | Nashville SC | 2-0 | DC United |
| 21:30 | Kansas City | 3-0 | Vancouver |
| 21:30 | St. Louis City | 2-0 | Colorado |
| 23:30 | SJ Earthquakes | 2-2 | L.A. Galaxy |
| 23:30 | Seattle Sounders | 1-0 | Houston Dynamo |
| Domingo 02 de Julio | |||
| 17:00 | Atlanta United | 2-0 | Philadelphia |
| Fecha 21 | |||
| Sábado 24 de Junio | |||
| 20:30 | Charlotte FC | 0-0 | Montreal |
| 20:30 | Columbus Crew | 2-0 | Nashville SC |
| 20:30 | DC United | 3-0 | Cincinnati |
| 20:30 | New England | 2-1 | Toronto FC |
| 20:30 | New York RB | 4-0 | Atlanta United |
| 20:30 | Philadelphia | 4-1 | Inter Miami |
| 21:30 | Austin FC | 3-0 | Houston Dynamo |
| 21:30 | Kansas City | 0-1 | Chicago Fire |
| 22:30 | Colorado | 0-0 | L.A. Galaxy |
| 22:30 | Real Salt Lake | 2-2 | Minnesota |
| 23:30 | Los Angeles FC | 2-3 | Vancouver |
| 23:30 | Portland Timbers | 1-1 | New York FC |
| 23:30 | SJ Earthquakes | 1-2 | St. Louis City |
| 23:30 | Seattle Sounders | 0-0 | Orlando City |
| Fecha 20 | |||
| Miércoles 21 de Junio, 20:30 | Atlanta United | 2-2 | New York FC |
| 20:30 | Montreal | 1-0 | Nashville SC |
| 20:30 | Cincinnati | 3-0 | Toronto FC |
| 20:30 | New York RB | 2-2 | Charlotte FC |
| 20:30 | Orlando City | 2-2 | Philadelphia |
| 21:30 | Austin FC | 3-0 | Dallas |
| 21:30 | Houston Dynamo | 4-1 | SJ Earthquakes |
| 21:30 | St. Louis City | 1-3 | Real Salt Lake |
| 23:30 | L.A. Galaxy | 2-2 | Kansas City |
| 23:30 | Los Angeles FC | 1-0 | Seattle Sounders |
| 23:30 | Portland Timbers | 1-2 | Chicago Fire |
| Sábado 09 de Septiembre, 21:30 | Minnesota | 1-1 | New England |
| Miércoles 27 de septiembre | Colorado | 2-2 | Vancouver |
| Fecha 19 | |||
| Sábado 17 de Junio | |||
| 16:30 | New York FC | 1-1 | Columbus Crew |
| 20:30 | DC United | 1-2 | Real Salt Lake |
| 20:30 | New England | 3-1 | Orlando City |
| 21:30 | Kansas City | 1-2 | Los Angeles FC |
| 21:30 | Nashville SC | 3-1 | St. Louis City |
| 23:30 | SJ Earthquakes | 0-0 | Portland Timbers |
| Fecha 18 | |||
| Sábado 10 de Junio | |||
| 20:30 | Atlanta United | 3-1 | DC United |
| 20:30 | Montreal | 4-0 | Minnesota |
| 20:30 | Charlotte FC | 3-3 | Seattle Sounders |
| 20:30 | New England | 3-1 | Inter Miami |
| 20:30 | Orlando City | 2-0 | Colorado |
| 20:30 | Toronto FC | 1-1 | Nashville SC |
| 21:30 | Chicago Fire | 1-2 | Columbus Crew |
| 21:30 | Houston Dynamo | 4-0 | Los Angeles FC |
| 21:30 | Kansas City | 4-1 | Austin FC |
| 22:30 | Real Salt Lake | 0-0 | New York FC |
| 23:30 | SJ Earthquakes | 2-1 | Philadelphia |
| 23:30 | Vancouver | 1-1 | Cincinnati |
| Domingo 11 de Junio | |||
| 14:00 | St. Louis City | 1-1 | L.A. Galaxy |
| 23:00 | Portland Timbers | 1-0 | Dallas |
| Fecha 17 | |||
| Sábado 03 de Junio | |||
| 16:30 | New York FC | 0-0 | New England |
| 17:30 | Seattle Sounders | 0-0 | Portland Timbers |
| 20:30 | Columbus Crew | 4-2 | Charlotte FC |
| 20:30 | Cincinnati | 1-0 | Chicago Fire |
| 20:30 | Inter Miami | 1-2 | DC United |
| 20:30 | New York RB | 0-3 | Orlando City |
| 20:30 | Philadelphia | 3-0 | Montreal |
| 21:30 | Austin FC | 1-2 | Real Salt Lake |
| 21:30 | Dallas | 1-2 | Nashville SC |
| 21:30 | Minnesota | 1-1 | Toronto FC |
| 21:30 | St. Louis City | 3-0 | Houston Dynamo |
| 22:30 | Colorado | 0-0 | SJ Earthquakes |
| 23:30 | Los Angeles FC | 0-0 | Atlanta United |
| 23:30 | Vancouver | 1-1 | Kansas City |
| Fecha 16 | |||
| Miércoles 31 de Mayo | |||
| 20:30 | Atlanta United | 3-3 | New England |
| 20:30 | Columbus Crew | 3-2 | Colorado |
| 20:30 | DC United | 2-2 | Montreal |
| 20:30 | Inter Miami | 0-1 | New York RB |
| 20:30 | New York FC | 1-3 | Cincinnati |
| 20:30 | Philadelphia | 1-0 | Charlotte FC |
| 20:30 | Toronto FC | 0-0 | Chicago Fire |
| 21:30 | Austin FC | 2-1 | Minnesota |
| 21:30 | Kansas City | 2-1 | Dallas |
| 22:30 | Real Salt Lake | 2-3 | L.A. Galaxy |
| Miércoles 12 de julio, 23:30 | Los Angeles FC | St. Louis City | |
| 23:30 | Seattle Sounders | 0-1 | SJ Earthquakes |
| 23:30 | Vancouver | 6-2 | Houston Dynamo |
| Fecha 15 | |||
| Sábado 27 de Mayo | |||
| 20:30 | Montreal | 1-0 | Inter Miami |
| 20:30 | New England | 3-3 | Chicago Fire |
| 20:30 | New York FC | 1-3 | Philadelphia |
| 20:30 | Orlando City | 1-1 | Atlanta United |
| 20:30 | Toronto FC | 2-1 | DC United |
| 21:30 | Houston Dynamo | 2-1 | Austin FC |
| 21:30 | Minnesota | 1-1 | Real Salt Lake |
| 21:30 | St. Louis City | 3-1 | Vancouver |
| 22:30 | Colorado | 0-1 | Cincinnati |
| 23:30 | L.A. Galaxy | 0-1 | Charlotte FC |
| 23:30 | SJ Earthquakes | 1-1 | Dallas |
| 23:30 | Seattle Sounders | 1-0 | New York RB |
| Domingo 28 de Mayo | |||
| 16:00 | Kansas City | 4-1 | Portland Timbers |
| 21:30 | Nashville SC | 3-1 | Columbus Crew |
| Fecha 14 | |||
| Sábado 20 de Mayo | |||
| 20:30 | Charlotte FC | 1-2 | Nashville SC |
| 20:30 | DC United | 3-0 | L.A. Galaxy |
| 20:30 | Cincinnati | 3-2 | Columbus Crew |
| 20:30 | Inter Miami | 1-3 | Orlando City |
| 20:30 | New York RB | 2-1 | Montreal |
| 20:30 | Philadelphia | 3-0 | New England |
| 21:30 | Austin FC | 1-0 | Toronto FC |
| 21:30 | Chicago Fire | 3-3 | Atlanta United |
| 21:30 | Dallas | 1-1 | Houston Dynamo |
| 22:30 | Colorado | 2-3 | Real Salt Lake |
| 22:30 | St. Louis City | 4-0 | Kansas City |
| 23:30 | Los Angeles FC | 2-1 | SJ Earthquakes |
| 23:30 | Portland Timbers | 0-1 | Minnesota |
| 23:30 | Vancouver | 2-0 | Seattle Sounders |
| Fecha 13 | |||
| Miércoles 17 de Mayo | |||
| 20:30 | Atlanta United | 4-0 | Colorado |
| 20:30 | Charlotte FC | 2-1 | Chicago Fire |
| 20:30 | Columbus Crew | 2-0 | L.A. Galaxy |
| 20:30 | Cincinnati | 3-0 | Montreal |
| 20:30 | Orlando City | 1-1 | New York FC |
| 20:30 | Philadelphia | 0-0 | DC United |
| 20:30 | Toronto FC | 0-0 | New York RB |
| 21:30 | Dallas | 2-1 | Vancouver |
| 21:30 | Minnesota | 1-0 | Houston Dynamo |
| 21:30 | Nashville SC | 2-1 | Inter Miami |
| 22:30 | Real Salt Lake | 0-0 | Portland Timbers |
| 23:30 | Los Angeles FC | 1-1 | Kansas City |
| 23:30 | Seattle Sounders | 1-2 | Austin FC |
| Fecha 12 | |||
| Sábado 13 de Mayo | |||
| 14:00 | Chicago Fire | 1-0 | St. Louis City |
| 20:30 | Atlanta United | 1-3 | Charlotte FC |
| 20:30 | Montreal | 2-0 | Toronto FC |
| 20:30 | Columbus Crew | 2-2 | Orlando City |
| 20:30 | DC United | 1-1 | Nashville SC |
| 20:30 | Inter Miami | 2-1 | New England |
| 20:30 | New York RB | 1-0 | New York FC |
| 21:30 | Austin FC | 0-1 | Dallas |
| 21:30 | Houston Dynamo | 0-1 | Seattle Sounders |
| 21:30 | Kansas City | 3-0 | Minnesota |
| 22:30 | Colorado | 1-2 | Philadelphia |
| 22:30 | Real Salt Lake | 0-3 | Los Angeles FC |
| 23:30 | Portland Timbers | 3-1 | Vancouver |
| Domingo 14 de Mayo | |||
| 22:30 | L.A. Galaxy | 2-1 | SJ Earthquakes |
| Fecha 11 | |||
| Sábado 06 de Mayo | |||
| 20:30 | Montreal | 2-0 | Orlando City |
| 20:30 | Charlotte FC | 3-2 | New York FC |
| 20:30 | Cincinnati | 2-1 | DC United |
| 20:30 | Inter Miami | 2-1 | Atlanta United |
| 20:30 | New York RB | 0-1 | Philadelphia |
| 20:30 | SJ Earthquakes | 2-1 | Los Angeles FC |
| 20:30 | Toronto FC | 0-2 | New England |
| 21:30 | Dallas | susp | St. Louis City |
| 21:30 | Houston Dynamo | 0-0 | Real Salt Lake |
| 21:30 | Nashville SC | 3-0 | Chicago Fire |
| 23:30 | L.A. Galaxy | 1-3 | Colorado |
| 23:30 | Portland Timbers | 2-2 | Austin FC |
| 23:30 | Vancouver | 3-2 | Minnesota |
| Domingo 07 de Mayo | |||
| 17:30 | Seattle Sounders | 1-2 | Kansas City |
| Fecha 10 | |||
| Sábado 29 de Abril | |||
| 14:30 | Nashville SC | 3-1 | Atlanta United |
| 20:30 | Columbus Crew | 1-2 | Inter Miami |
| 20:30 | DC United | 3-0 | Charlotte FC |
| 20:30 | New England | 1-1 | Cincinnati |
| 20:30 | Orlando City | 2-0 | L.A. Galaxy |
| 20:30 | Toronto FC | 1-0 | New York FC |
| 21:30 | Austin FC | 2-2 | SJ Earthquakes |
| 21:30 | Chicago Fire | 1-1 | New York RB |
| 21:30 | Kansas City | 0-2 | Montreal |
| 21:30 | St. Louis City | 1-2 | Portland Timbers |
| 22:30 | Real Salt Lake | 0-0 | Seattle Sounders |
| POST 14 de junio | Los Angeles FC | Houston Dynamo | |
| 23:30 | Vancouver | 0-0 | Colorado |
| Domingo 30 de Abril | |||
| 22:00 | Minnesota | 0-0 | Dallas |
| Fecha 9 | |||
| Sábado 22 de Abril | |||
| 20:30 | Montreal | 2-0 | New York RB |
| 20:30 | Charlotte FC | 1-0 | Columbus Crew |
| 20:30 | Cincinnati | 2-1 | Portland Timbers |
| 20:30 | New England | 2-1 | Kansas City |
| 20:30 | New York FC | 3-1 | Dallas |
| 20:30 | Orlando City | 1-3 | DC United |
| 20:30 | Philadelphia | 4-2 | Toronto FC |
| 21:30 | Houston Dynamo | 1-0 | Inter Miami |
| 21:30 | Nashville SC | 1-1 | Los Angeles FC |
| 22:30 | Colorado | 1-1 | St. Louis City |
| 22:30 | Real Salt Lake | 3-1 | SJ Earthquakes |
| 23:30 | L.A. Galaxy | 2-0 | Austin FC |
| 23:30 | Seattle Sounders | 1-0 | Minnesota |
| Domingo 23 de Abril | |||
| 17:30 | Atlanta United | 2-1 | Chicago Fire |
| Fecha 8 | |||
| Sábado 15 de Abril | |||
| 20:30 | Montreal | 0-1 | DC United |
| 20:30 | Charlotte FC | 2-2 | Colorado |
| 20:30 | Columbus Crew | 1-1 | New England |
| 20:30 | New York FC | 2-1 | Nashville SC |
| 20:30 | New York RB | 1-1 | Houston Dynamo |
| 20:30 | Toronto FC | 2-2 | Atlanta United |
| 21:30 | Austin FC | 0-0 | Vancouver |
| 21:30 | Chicago Fire | 2-2 | Philadelphia |
| 21:30 | Dallas | 2-1 | Real Salt Lake |
| 21:30 | Minnesota | 1-2 | Orlando City |
| 21:30 | St. Louis City | 5-1 | Cincinnati |
| 23:30 | Portland Timbers | 4-1 | Seattle Sounders |
| 23:30 | SJ Earthquakes | 3-0 | Kansas City |
| Domingo 16 de Abril | |||
| 17:30 | L.A. Galaxy | 2-3 | Los Angeles FC |
| Fecha 7 | |||
| Sábado 08 de Abril, 20:30 | DC United | 0-2 | Columbus Crew |
| 20:30 | Cincinnati | 1-0 | Philadelphia |
| 20:30 | Inter Miami | 0-1 | Dallas |
| 20:30 | Los Angeles FC | 3-0 | Austin FC |
| 20:30 | New England | 4-0 | Montreal |
| 20:30 | New York FC | 1-1 | Atlanta United |
| 20:30 | New York RB | 1-1 | SJ Earthquakes |
| 21:30 | Chicago Fire | 2-1 | Minnesota |
| 21:30 | Houston Dynamo | 3-0 | L.A. Galaxy |
| 21:30 | Nashville SC | 0-0 | Toronto FC |
| 21:30 | Kansas City | 0-1 | Colorado |
| 22:30 | Real Salt Lake | 3-1 | Charlotte FC |
| 23:30 | Seattle Sounders | 3-0 | St. Louis City |
| 23:30 | Vancouver | 1-0 | Portland Timbers |
| Fecha 6 | |||
| Sábado 01 de Abril | |||
| 21:30 | Atlanta United | 1-0 | New York RB |
| 21:30 | Columbus Crew | 4-0 | Real Salt Lake |
| 21:30 | Cincinnati | 1-0 | Inter Miami |
| 21:30 | L.A. Galaxy | 1-2 | Seattle Sounders |
| 21:30 | New England | 1-1 | New York FC |
| 21:30 | Orlando City | 0-2 | Nashville SC |
| 21:30 | Philadelphia | 0-0 | Kansas City |
| 21:30 | Toronto FC | 2-2 | Charlotte FC |
| 22:30 | Chicago Fire | 0-0 | DC United |
| 22:30 | Dallas | 1-1 | Portland Timbers |
| 22:30 | St. Louis City | 0-1 | Minnesota |
| 23:30 | Colorado | 0-0 | Los Angeles FC |
| Domingo 02 de Abril | |||
| 00:30 | SJ Earthquakes | 2-1 | Houston Dynamo |
| 00:30 | Vancouver | 5-0 | Montreal |
| Fecha 5 | |||
| Sábado 25 de Marzo | |||
| 17:30 | Portland Timbers | 0-0 | L.A. Galaxy |
| 20:30 | Charlotte FC | 1-1 | New York RB |
| 20:30 | Columbus Crew | 6-1 | Atlanta United |
| 20:30 | DC United | 1-2 | New England |
| 20:30 | Inter Miami | 2-3 | Chicago Fire |
| 20:30 | Philadelphia | 1-2 | Orlando City |
| 21:30 | Austin FC | 1-1 | Colorado |
| 21:30 | Houston Dynamo | 1-0 | New York FC |
| 21:30 | Minnesota | 1-1 | Vancouver |
| 21:30 | Nashville SC | 0-1 | Cincinnati |
| 21:30 | Kansas City | 1-4 | Seattle Sounders |
| 23:30 | Real Salt Lake | 0-4 | St. Louis City |
| Domingo 26 de Marzo | |||
| 00:30 | Los Angeles FC | 2-1 | Dallas |
| 00:30 | SJ Earthquakes | 0-0 | Toronto FC |
| Fecha 4 | |||
| Sábado 18 de Marzo | |||
| 17:00 | Seattle Sounders | 0-0 | Los Angeles FC |
| 20:30 | Atlanta United | 5-1 | Portland Timbers |
| 20:30 | Montreal | 3-2 | Philadelphia |
| 20:30 | New England | 1-0 | Nashville SC |
| 20:30 | New York FC | 3-2 | DC United |
| 20:30 | New York RB | 2-1 | Columbus Crew |
| 20:30 | Orlando City | 1-2 | Charlotte FC |
| 20:30 | Toronto FC | 2-0 | Inter Miami |
| 21:30 | Chicago Fire | 3-3 | Cincinnati |
| 21:30 | Dallas | 2-1 | Kansas City |
| 21:30 | Houston Dynamo | 2-0 | Austin FC |
| 21:30 | St. Louis City | 3-0 | SJ Earthquakes |
| 22:30 | Colorado | 1-2 | Minnesota |
| 23:30 | L.A. Galaxy | 1-1 | Vancouver |
| Fecha 3 | |||
| Sábado 11 de Marzo | |||
| 14:00 | Charlotte FC | 0-3 | Atlanta United |
| 19:00 | Vancouver | 1-1 | Dallas |
| 21:30 | DC United | 1-1 | Orlando City |
| 21:30 | Cincinnati | 1-0 | Seattle Sounders |
| 21:30 | New York FC | 1-0 | Inter Miami |
| 21:30 | Philadelphia | 1-0 | Chicago Fire |
| 21:30 | Toronto FC | 1-1 | Columbus Crew |
| 22:30 | Minnesota | 1-1 | New York RB |
| 22:30 | Nashville SC | 2-0 | Montreal |
| 22:30 | Kansas City | 0-0 | L.A. Galaxy |
| 23:30 | Real Salt Lake | 1-2 | Austin FC |
| Domingo 12 de Marzo | |||
| 00:30 | Portland Timbers | 1-2 | St. Louis City |
| 00:30 | SJ Earthquakes | 1-0 | Colorado |
| 23:30 | Los Angeles FC | 4-0 | New England |
| Fecha 2 | |||
| Sábado 04 de Marzo | |||
| 18:30 | Los Angeles FC | 3-2 | Portland Timbers |
| 21:30 | Atlanta United | 1-1 | Toronto FC |
| 21:30 | Columbus Crew | 2-0 | DC United |
| 21:30 | Inter Miami | 2-0 | Philadelphia |
| 21:30 | New England | 3-0 | Houston Dynamo |
| 21:30 | New York RB | 0-0 | Nashville SC |
| 21:30 | Orlando City | 0-0 | Cincinnati |
| 22:30 | Austin FC | 1-0 | Montreal |
| 22:30 | Chicago Fire | 1-1 | New York FC |
| 22:30 | Dallas | 3-1 | L.A. Galaxy |
| 22:30 | St. Louis City | 3-1 | Charlotte FC |
| 23:30 | Colorado | 0-0 | Kansas City |
| Domingo 05 de Marzo | |||
| 00:30 | SJ Earthquakes | 2-1 | Vancouver |
| 00:30 | Seattle Sounders | 2-0 | Real Salt Lake |
| Fecha 1 | |||
| Sábado 25 de Febrero, 18:30 | Nashville SC | 2-0 | New York FC |
| 21:30 | Atlanta United | 2-1 | SJ Earthquakes |
| 21:30 | Charlotte FC | 0-1 | New England |
| 21:30 | DC United | 3-2 | Toronto FC |
| 21:30 | Cincinnati | 2-1 | Houston Dynamo |
| 21:30 | Inter Miami | 2-0 | Montreal |
| 21:30 | Orlando City | 1-0 | New York RB |
| 21:30 | Philadelphia | 4-1 | Columbus Crew |
| 22:30 | Austin FC | 2-3 | St. Louis City |
| 22:30 | Dallas | 0-1 | Minnesota |
| Domingo 26, 00:30 | Vancouver | 1-2 | Real Salt Lake |
| 22:00 | Seattle Sounders | 4-0 | Colorado |
| Martes 28, 00.05 | Portland Timbers | 1-0 | Kansas City |
| Miércoles 5 de julio, 00.30 | L.A. Galaxy | Los Angeles FC |
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